After Godzilla's return in 1984 in The Return of Godzilla, the city of Tokyo, Japan had suffered a great deal of destruction. During the aftermath and cleanup, forensic workers collected small remains of skin from Godzilla, which were later transported to a government lab facility in the arid wasteland of Saradia. A scientist by the name of Dr. Shiragami intended to use the genetic material of the Godzilla cells to genetically enhance various species of plants to transform the land of Saradia with rich crops resistant to harsh weather and unfavorable conditions. Unfortunately, numerous other nations did not approve of this move in agricultural wealth-as Saradia relied on exports for its produce-and an act of terrorism was put into plan to bomb the laboratory working with the cells. Amongst the scientists who lost their lives was Erika Shiragami, Dr. Shiragami's daughter. His loss was graving to him, and he proceeded to collect DNA from his daughter and splice it with that of a rosebush in hopes of preserving his daughter's spiritual entity. Five years later, in 1989, an earthquake destroyed the roses' shelter, thereby killing several. Dr. Shiragami became panicked, and carried out a risky and unauthorized plan to splice the Godzilla DNA with a lone rose, in hopes that the rose would remain alive and hopefully invincible. However, the seemingly successful fusion of the cells resulted in the slow but eventual growth and mutation of the rose, which eventually became capable of thinking and moving, and eventually proceeded to smash its way through the laboratory wall, making its way to Lake Ashino, where it rooted itself and took up residence.Biollante's first encounter with Godzilla was inevitable. Godzilla had actually sensed the presence of another living being with the same genetic makeup as himself, and felt an uncontrollable urge to travel to the originating site of this feeling. It was also mentioned by Miki Saegusa, an individual endowed with ESP, that Biollante had been "calling out to Godzilla" (whether or not this calling was intentional was never explained). Biollante, in her first encounter, fought defensively with wave after wave of tangling vines. Despite the great effort that the plant/monster hybrid exerted, it failed miserably and took heavy damage from Godzilla's atomic beam. Godzilla eventually managed to set Biollante aflame, and Biollante seemingly burned to death. However, it was reaffirmed that Biollante was immortal as everyone watched Biollante begin dissolving into energy particles to ascend into space. Later on, Biollante confronted Godzilla again, this time at her own will. Their second battle had clearly turned the offensive/defensive tables. Now, Biollante was clearly pursuing and fighting Godzilla offensively, whereas Godzilla was now fighting with all his might to defend against such a colossus who fought more mercilessly than the King of the Monsters himself. The outcome of the battle resulted in Godzilla retreating as Anti-Nuclear Energy Bacteria began to take effect, slowly weakening him. He clumsily lumbered to the coast, collapsing into the sea face first, laying apparently unconscious. Biollante, on the other hand, had also suffered a devastating blow when Godzilla fired a blast of his beam directly into Biollante's throat, blowing out her back. She was forced to retreat as well, and dissolved into spores again and ascended into space, likely never to be seen again. Shortly after, Godzilla regained strength from the cooling waters of the ocean (which stopped the breeding of the bacteria) and headed out to sea to recuperate.